Computational barcoding of drug and disease physiology.
Shadow BioSystems creates computational barcodes that capture the biological footprint of drugs and diseases. By representing both in the same physiological language, we can identify hidden therapeutic relationships, reveal mechanism, and uncover opportunities for drug discovery and repurposing.
Drugs and diseases don't speak the same language.
We built one.
Drugs are described by targets, binding affinities, and adverse events. Diseases are described by symptoms, pathways, and molecular dysfunction.Shadow BioSystems projects both into a shared physiological coordinate space built from adverse event data, target binding, tissue expression, and biological function.The distance between a drug's full biological footprint and its approved indication becomes a signal for repurposing, mechanism discovery, and therapeutic opportunity identification.832 drugs × 479 diseases scored83.2% approved-drug label recovery via blinded validation. No label leakage.
Our Founder
Jon is the Founder and CEO of Shadow BioSystems and architect of its core algorithm.He previously led research and operations at a Silicon Valley deeptech startup developing translational 3D-printed lung models for preclinical drug development.Shadow BioSystems builds computational barcodes of drug and disease physiology to enable mechanism discovery and therapeutic prediction.
Let's talk
For investment, collaboration, or research partnerships.